SPORT NUTRITION AND ADVERSE REACTIONS TO FOODSTUFFS
MULTIFACTORIAL ANALYSIS BASED ON PANTOJA-ARÉVALO L. et al.
The Pantoja-Arévalo L. et al multifactorial analysis is part of the clinical and nutritional research led by Dr. Lisset Pantoja-Arévalo, primarily developed through the ALASKA Study at the Universidad Politécnica de Madrid.
This multifactorial analysis, based on the work of Pantoja-Arévalo L. et al. in sports nutrition, is the scientific evaluation of the components of the human body (muscle mass, fat, water, and minerals) combined with the determination of clinical biomarkers specifically related to adverse reactions to foodstuffs (ARFS) (hematological, biochemical, immunological, etc.) to design personalized nutrition and training strategies that optimize physical condition and performance.
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This scientific approach simultaneously evaluates multiple biological, behavioral, and environmental variables to identify, manage, and mitigate adverse reactions to foodstuffs (ARFS) in adulthood.
Unlike traditional approaches focused solely on isolated allergens, this analysis correlates diet with factors such as body composition, physical performance, gut microbiota, and inflammation.
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CORE PRINCIPLES OF THE PROTOCOL
The protocol integrates various physical and clinical tools divided into the following fundamental pillars:
- Clinical information and demographics: Individual’s profile in healthcare, including a person’s identifying background and their medical/vaccine histories.
- Food Frequency consumption and Symptomatology using validated questionnaires: Use of custom-designed tools such as the Food and Beverages Frequency Consumption Questionnaire to Identify Adverse Reactions to Foodstuffs (FBFC-ARFSQ-18); and the Pathologies and Symptomatology Questionnaire associated with Adverse Reactions to Foodstuffs (PSIMP-ARFSQ-10).
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3. Clinical Assessments: Hematological, biochemical, immunological, enzymatic and genetic analysis.
4. Physical Assessments: body composition, cardiorespiratory fitness and strength.
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5. Health-related Quality of life: analysis of the impact of physical and mental health on everyday functioning and well-being.
6. Recommendations of a personalized- substitutive diet based on the clinical and physical assessments.
7. Follow-up every 3 to 6 months.
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- Pantoja-Arévalo L, Gesteiro E, Pérez-Ruiz M, Tang S, Urrialde R, González-Gross M. Is There a Relationship Between Physical Performance Factors and Adverse Reactions to Foodstuffs? The ALASKA Study. Nutrients. 2024 Dec 20;16(24):4384. doi: 10.3390/nu16244384. PMID: 39771005; PMCID: PMC11676144. ↩︎
- Pantoja-Arévalo L, Gesteiro E, Pérez-Ruiz M, López-Seoane J, Wusterhausen P, Matthias T, Urrialde R, González-Gross M. The multifactorial approach and the food allergen-specific substitutive diet as a tool to manage and ameliorate adverse reactions to foodstuffs in adulthood: study protocol for a randomized controlled trial-the ALASKA study. Trials. 2024 Jul 20;25(1):494. doi: 10.1186/s13063-024-08307-2. PMID: 39033266; PMCID: PMC11264907. ↩︎
- Pantoja-Arévalo L, Gesteiro E, Calonge-Pascual S, Pérez-Ruiz M, Urrialde R, González-Gross M. Design and validity of the Spanish version of two questionnaires related to adverse reactions to foodstuffs. Nutr Hosp. 2023 Aug 28;40(4):800-810. English. doi: 10.20960/nh.04631. PMID: 37409709. ↩︎
- Pantoja-Arévalo L, Gesteiro E, Matthias T, Urrialde R, González-Gross M. Association between Food-Specific Immunoglobulin G4 Antibodies in Adults with Self-Reported Signs and Symptoms Attributed to Adverse Reactions to Foodstuffs. Biomedicines. 2023 Dec 17;11(12):3335. doi: 10.3390/biomedicines11123335. PMID: 38137556; PMCID: PMC10742047. ↩︎
- Pantoja-Arévalo L, Modrego J, Gómez-Garre D, Gesteiro E, González-Gross M. Dairy-Gut Microbiome Interactions: Implications for Immunity, Adverse Reactions to Food, Physical Performance and Cardiometabolic Health-A Narrative Review. Nutrients. 2025 Oct 21;17(20):3312. doi: 10.3390/nu17203312. PMID: 41156563; PMCID: PMC12567453. ↩︎
