The Advanced Biomaterials and Mechanobiology Group at the Center for Biomedical Technology is a partner in the TecNanoBio project, funded by the Comunidad de Madrid (Tecnologías Multiescala para el Avance de la Nanociencia en Sistemas Biológicos, Reference: TEC-2024/TEC-158; Duration: Jan 2025-Dec 2028).
You can find more information about the project on its web.
TecNanoBio brings together a consortium of engineers, chemists, physicists, and biologists from several leading institutions within Madrid’s research ecosystem: the Spanish National Research Council (Centro Nacional de Biotecnología), the Carlos III Health Institute (CNIC and CNIO), IMDEA Nanociencia, and Universidad Politécnica de Madrid. The consortium is dedicated to the development of novel multiscale technologies at the forefront of nanoscience and their application to the study of biological mechanisms involved in cancer and cardiovascular disease. The proposed objectives are both scientifically and technically highly ambitious and can only be achieved through the close collaboration of the consortium’s research groups. Beyond the project’s specific goals, this collaboration will strengthen synergies among major research institutions, generating an impact that extends well beyond the scope of the project itself.
Our laboratory contributes to the development of innovative technologies for the biophysical characterization of biological systems across multiple length scales. Firstly, we focus on advancing atomic force microscopy (AFM)-based affinity microscopy approaches for the quantitative characterization of biomolecular interactions at the molecular level. Secondly, we develop microfluidic platforms incorporating geometrical constrictions to enable high-throughput mechanical characterization of individual cells. Finally, we are developing a novel technology for the biomechanical characterization of cell monolayers. Together, these complementary approaches establish a multiscale framework for studying biological function from molecules to tissues.
